Isoniazid Induces Its Own Resistance in Nonreplicating Mycobacterium tuberculosis

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Isoniazid induces its own resistance in nonreplicating Mycobacterium tuberculosis.

Isoniazid (INH) resistance is most frequent among drug-resistant Mycobacterium tuberculosis clinical isolates. This study was conducted to investigate whether INH could induce its own resistance. During INH susceptibility testing in BACTEC 12B and MGIT 960 media, weekly subcultures were made from the drug-containing media into fresh medium without drug and susceptibility testing was performed. ...

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BACKGROUND Understanding how growth state influences Mycobacterium tuberculosis responses to antibiotic exposure provides a window into drug action during patient chemotherapy. In this article, we describe the transcriptional programs mediated by isoniazid (INH) during the transition from log-phase to nonreplicating bacilli, from INH-sensitive to INH-tolerant bacilli respectively, using the Way...

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In silico Analysis of Isoniazid Resistance in Mycobacterium tuberculosis

Altered drug binding may be an important factor in isoniazid (INH) resistance, rather than major changes in the enzyme’s activity as a catalase or peroxidase (KatG). The identification of structural or functional defects in the mutant KatGs responsible for INH resistance remains as an area to be explored. In this connection, the differences in the binding affinity between wild-type (WT) and mut...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2007

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.00086-07